A bile acid – a cholesterol-derived bioactive lipid, lithocholic acid has been recently suggested to cause considerable lifespan extension in yeast. Vladimir Titorenko, from Concordia University (Canada), and colleagues have revealed that when entering a cancer cell, lithocholic acid attacks the cells’ mitochondria to cause cell death. Submitting that: “[lithocholic acid] exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms,” the study authors posit that: “The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged.”
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Anthony Arlia-Ciommo, Amanda Piano, Veronika Svistkova, Sadaf Mohtashami, Vladimir Titorenko. “Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid.” International Journal of Molecular Sciences, 2014; 15 (9): 16522 DOI: 10.3390/ijms150916522.
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