In that phytoestrogens have been studied as potential alternatives to hormone replacement therapy (HRT) and as chemopreventive reagents for breast cancer, Takako Sakamoto, from Jichi Medical University (Japan), and colleagues studied resveratrol, a compound derived from grape skins, and its e effects on breast cancer development and progression. The team found that resveratrol increased apoptosis, reduced the Bcl-2/Bax ratio, and significantly enhanced p53-dependent transcriptional activity. Resveratrol also exhibited other cancer silencing effects, leading the team to conclude that: “resveratrol might be the most promising candidate for HRT and chemoprevention of breast cancer due to its estrogenic activity and high antitumor activity.”
Resveratrol Holds Promose as HRT Alternative
Takako Sakamoto, Hyogo Horiguchi, Etsuko Oguma, Fujio Kayama. “Effects of diverse dietary phytoestrogens on cell growth, cell cycle and apoptosis in estrogen-receptor-positive breast cancer cells.” The Journal of Nutritional Biochemistry, In Press, Corrected Proof, Available online 3 October 2009; doi:10.1016/j.jnutbio.2009.06.010 .
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