Subjecting the skeletal muscle stem cells population from aged mice to transient inhibition of p38[alpha] and p38[beta] in conjunction with culture on soft hydrogel substrates rapidly expands the residual functional skeletal muscle stem cells population from aged mice, rejuvenating its potential for regeneration and serial transplantation as well as strengthening of damaged muscles of aged mice.
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
Cosgrove BD, Gilbert PM, Porpiglia E, Mourkioti F, Lee SP, Corbel SY, Llewellyn ME, Delp SL, Blau HM. Nat Med. 2014 Mar;20(3):255-64.
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