The over-expression and over-activation of matrix metalloproteinases (MMPs), enzymes that degrade collagen, play a key role in skin health as well as joint conditions such as arthritis. Navindra Seeram, from the University of Rhode Island (Rhode Island, USA), and colleagues investigated the therapeutic potential of punicalagins – compounds found in the pomegranate fruit. The team observed that the punicalagins inhibited MMPs in the cell studies, and reduced inflammation in the animal models of arthritis.
Pomegranate Compounds May Benefit Joint & Skin Health
Jean-Gilles D, Li L, Vaidyanathan VG, King R, Cho B, Worthen DR, Chichester CO 3rd, Seeram NP. “Inhibitory effects of polyphenol punicalagin on type-II collagen degradation in vitro and inflammation in vivo.” Chem Biol Interact. 2013 Sep 25;205(2):90-9.
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