Plasminogen activator inhibitor-1 (PAI-1) deficiency retards the development of senescence and protects organ structure and function while prolonging the lifespan.
PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice
Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GR, Mutlu GM, Miyata T, Vaughan DE. Proc Natl Acad Sci U S A. 2014 Apr 28.
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