Molecular Mechanism Involved in Energy Expenditure Identified

In that ATP (adenosine triphosphate) provides cells with the energy to conduct their various processes, Mayo Clinic (Minnesota, USA) researchers have found that energy expenditure is controlled by the ATP-sensitive potassium (KATP) channel.  Using a mouse model, the team determined that mice that lack the KATP channel burn more stored energy through the dissipation of heat at normal activity levels or when resting.  In other words, a lack of KATP channels results in inefficient thermogenesis, depleting muscle stores.  The team proposes that an approach to treating obesity may involve targeting KATP channels, making muscle less efficient.