Metformin, the world’s most widely used anti-diabetic drug, causes an increase in the number of toxic oxygen molecules released in the cell, to increase cell robustness and longevity in the long term.
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
De Haes W, Frooninckx L, Van Assche R, Smolders A, Depuydt G, Billen J, Braeckman BP, Schoofs L, Temmerman L. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):E2501-9.
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