Vitamin E is a nutrient that is essential in scavenging free radicals and preventing oxidative stress – a key process implicated in aging and aging-related diseases. Among obese adults, nonalcoholic steatohepatitis (NASH) is a liver disease that is characterized by fat accumulation, oxidative stress and liver inflammation. Danny Manor, from Case Western Reserve University (Ohio, USA), and colleagues studied a mouse model that was engineered to omit a protein that regulates Vitamin E levels. Oxidative stress rose, and fat deposition and liver injury resulted. However, the researchers observed that vitamin E supplementation averted the majority of NASH-related symptoms.
Liver Health “E”ssentials
Stacey Chung, Varsha Thakur, Jeffrey Atkinson, Robert Parker, Danny Manor. “Dynamic regulation of hepatic vitamin E secretion by the {alpha}- tocopherol transfer protein.” FASEB J., April 9, 2013; 27:373.1.
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