Rapid inhibition of transgenic amyloid precursor protein (APP) modulates the production of A[beta] without affecting pre-existing amyloid deposits and restored cognitive performance to the level of healthy controls.
Genetic modulation of soluble A[beta] rescues cognitive and synaptic impairment in a mouse model of Alzheimer’s disease
Fowler SW, Chiang AC, Savjani RR, Cirrito JR, Lesne SE, Jankowsky JL, et al. J Neurosci. 2014 Jun 4;34(23):7871-85.
RELATED ARTICLES
