This pilot small scope study included 24 lean and healthy participants of both sexes between the ages of 55-79. 12 of which were given a placebo for the first 6 weeks followed by 500 milligrams of NR chloride twice a day for another 6 weeks; the remaining 12 were given the supplement first for 6 weeks then placebo for the final 6 weeks. After each treatment period blood samples and other health tests were taken from the participants, no adverse effects were reported.
The scientists noted the supplement was well tolerated and appeared to activate some of the biological pathways that are activated by calorie restriction, and that this is the first study of its kind in humans.
13 participants had mildly elevated blood pressure at the start of the study, they benefited from an average 10 point reduction in their systolic blood pressure readings as a result of the supplement, according to the team this translates to a 25% reduction in the risk of heart attack.
1,000 mg of NR daily was reported to boost levels of NAD+ by 60%; Nicotinamide adenine dinucleotide tends to decline with age, and is required for activation of sirtuins enzymes that are credited with beneficial effects of calorie restriction, and is also involved with a host of metabolic action throughout the body.
As an evolutionary survival mechanism the body conserves nicotinamide adenine dinucleotide when subject to calorie restriction, recently scientist have begun to explore the idea of supplementing with NAD+/- precursors like NR to promote healthy aging.
Supplementing older adults with NR may restore nicotinamide adenine dinucleotide that is lost with aging, and potentially boost activity of enzyme responsible for helping to protect the body from stress, says Chris Martens, study lead author. The study provides a glimpse of chance that humans could live longer and healthier lives in the future.
