Previous studies of bitter orange (Citrus aurantium), containing the alkaloid p-synephrine, have suggested potential utility for weight management. Sidney J. Stohs, from Creighton University (Nebraska, USA), and colleagues tested the potential of p-synephrine alone, or p-synephrine plus the citrus flavonoids naringin and hesperidin, on the metabolic rate of 50 study subjects. Results showed that the p-synephrine alone increased the metabolic rate by 7%, ascompared to placebo. When 50mg of p-synephrine was consumed with 600 mg naringin and 100 mg hesperidin, the metabolic rate was almost 18% higher than the control group. No adverse effects to heart rate or blood pressure were observed. The researchers propose that: “This unusual finding of a thermogenic combination of ingredients that elevated metabolic rates without corresponding elevations in blood pressure and heart-rates warrants longer term studies to assess its value as a weight control agent.”
Citrus Extracts Help Promote Healthy Metabolic Function
Sidney J. Stohs, Harry G Preuss, Samuel C. Keith, Patti L. Keith, Howard Miller, Gilbert R. Kaats. “Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes.” Int. J. Med. Sci. 2011; 8: 295-301
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