Antisense oligonucleotide improves learning and memory, reduces A[beta] protein precursor and cytokine levels, in animals engineered to have increased brain levels of beta amyloid. Antisense reverses the beta amyloid-induced learning and memory deficits.
Central and peripheral administration of antisense oligonucleotide targeting amyloid-[beta] protein precursor improves learning and memory and reduces neuroinflammatory cytokines in Tg2576 (A[beta]PPswe) mice
Farr SA, Erickson MA, Niehoff ML, Banks WA, Morley JE. J Alzheimers Dis. 2014;40(4):1005-16.
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