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Apples Promote Immune Health

Chronic inflammation, linked to medical conditions including heart disease, diabetes, Alzheimer’s Disease, and more, may be accelerated as a result of consuming diets high in fat.  Christina L. Sherry, from the University of Illinois (USA), and colleagues investigated whether soluble fiber might counteract the negative health effects resulting from a high-fat diet.  The team fed lab animals either a low-fat diet with soluble or insoluble fiber, and found that the animals exhibited dramatically distinct responses when their immune system was challenged: animals fed soluble fiber were found to display less sickness and a faster recovery rate.  Explaining that: “Peripheral activation of the immune system by infectious agents triggers the brain–cytokine system causing sickness behaviors which profoundly impact well-being,” the researchers write that:   “These data show that a diet rich in soluble fiber protects against endotoxin-induced sickness behavior by … promoting alternative activation of macrophages.”

Christina L. Sherry, Stephanie S. Kim, Ryan N. Dilger, Laura L. Bauer, Morgan L. Moon, Richard I. Tapping, George C. Fahey Jr., Kelly A. Tappenden, Gregory G. Freund.  “Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization.” Brain, Behavior, and Immunity, 6 February 2010.

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