Inactivation of Yeast Isw2 Chromatin Remodeling Enzyme Mimics Longevity Effect of Calorie Restriction via Induction of Genotoxic Stress Response

Deletion of ISW2, or mutations inactivating the Isw2 enzyme complex, extends yeast replicative lifespan. With transcriptome analysis indicating that isw2[delta] partially mimics an upregulated stress response in calorie-restricted cells,, isw2[delta] cells show an increased response to genotoxic stresses.