GENERAL DESCRIPTION:
Produced in the mitochondria throughout the
body from cholesterol, pregnenolone is the base material of all human steroid manufacture, including DHEA, progesterone, testosterone, and
estrogen. It appears to block the effects of cortisol, thus
helping to prevent stress-mediated cell injury. Pregnenolone
stimulates brain NMDA receptors. These receptors, which decline with age, play an important
role in the function of synapses and neurons, influencing
learning and memory. Pregnenolone levels are directly
correlated with cognitive ability. Pregnenolone levels
decline with age.
ROLE FOR ANTI-AGING:
Pregnenolone’s anti-aging benefits may
include reduction of stress, reduction of arthritic inflammation, potential maintenance of
memory capability, improved mood, positive outlook and
well-being and improved sleep patterns.
DEFICIENCY SYMPTOMS:
Pregnenolone is not associated with a deficiency
state.
THERAPEUTIC DAILY AMOUNT:
The typical recommended dose of pregnenolone
is 30mg, however some studies have used
as much as 700mg per day. Pregnenolone is available in 5mg,
10mg, 20mg, 25mg, 30mg, 50mg, and 100mg
capsules.
MAXIMUM SAFE LEVEL:
established
SIDE EFFECTS/CONTRAINDICATIONS:
There have reports of rash occurring with
use but otherwise there are few side effects. Pregnant and nursing women, children, and people with
kidney or liver disease should not take pregnenolone. In
people with prostate conditions, use of pregnenolone
should be monitored carefully.
